For this study, mature cerebral organoids (6-7 months old) were transferred to a Mesh MEA using a polyethyleneimine and laminin coating protocol and BrainPhys cell culture media. After 3 weeks in culture, COs displayed higher electrical activity on the Mesh MEA compared to planar MEA chips, which contained either flat or 3D-spike electrodes.
In the Abilez et al. study, the HEKA EPC 10 Patch Clamp Amplifier provided the sensitivity, stability, and control needed to investigate individual cells within the complex 3D environment of the organoid.
Through our collaboration with Multi Channel Systems, the Ophthalmology Department at Radboudumc in the Netherlands is utilizing Mesh MEAs to capture dynamic retinal activity.
Organoid research is revolutionizing our understanding of human biology by providing three-dimensional, physiologically relevant models of human tissues. Key techniques include patch clamp electrophysiology, microelectrode arrays (MEAs), and optical manipulation, each of which unique advantages for studying the functional properties of organoids.
Our free guide compiles a range of experimental protocols to help guide researchers through the processes of culturing and seeding different types of organoids.
Retinitis pigmentosa (RP) and retinal dystrophy are debilitating genetic disorders that lead to progressive vision loss due to the degeneration of photoreceptor cells in the retina. Despite advances in genetic research, effective treatments remain limited, making the development of innovative research models crucial. Organoids and Mesh MEA (microelectrode array, also referred to as multielectrode array) technology from Multi Channel Systems have emerged as powerful tools in studying these diseases, providing insights into retinal function and potential therapeutic approaches.
The integration of behavioral telemetry and organoid research is transforming neuroscience and biomedical science by linking cellular models with complex biological behaviors.
Organoid technology is poised to revolutionize the development of brain-controlled prosthetics. By bridging the gap between the body’s central nervous system and a synthetic device, research with neural organoids could lead to the development of prosthetics capable of real-time interaction with the human brain through closed-loop feedback systems. Multielectrode array technology (also called “microelectrode array” or “MEA”) from Multi Channel Systems is ideally suited for studying this complex interaction and developing innovations in prosthetic research.
